Abstract: Well-being is the result of multi-factor interaction.The three themes on which we focus are: the neurobiology of genetic and health,the individual's internal capacity and personality to build on the impact of well-being and the social environment and interference strategies,which expected to have a new understanding of an integrated perspective of well-being.The current trend concerned about the interaction between internal and external factors influencing well-being,is the interaction of environmental and psychological,to expect an integrated sense of happiness with a new understanding.