Abstract: The platform economy efficiently connects supply and demand through digitalization and the Internet, lowers market entry barriers, and facilitates the integration of intra-regional and inter-regional markets. Based on the two-way fixed effect model, panel quantile model and other methods, this paper empirically examines the impact of platform economy and market segmentation on regional economic growth from the perspective of market segmentation. The study finds that there is a “U-shaped” relationship between platform economy development and regional economic growth; with the development of the platform economy, it can effectively boost regional economic growth by restraining market segmentation. Heterogeneity analysis shows that the platform economy can optimize the integration level of regions with medium-high and high economic development levels and promote their economic growth.