Abstract: Adhering to integrity and innovation is one of the major principles that need to be implemented in the comprehensive deepening of reform in the new era. The CPC’s adherence to integrity and innovation is a profound interpretation and vivid interpretation of Marxist philosophy ontology and practical epistemology. Adherence to integrity and innovation realizes the value orientation of Marxist historical materialism on the basis of consciously following Marxist materialistic dialectics. The glorious struggle of the CPC for more than 100 years clearly shows the historical prospect of the Party’s adherence to integrity and innovation in different contexts of the times， and the realization of socialist modernization and the great rejuvenation of the Chinese nation. In the new era， adhering to integrity and innovation has clearly defined the practical direction of the CPC to write a new chapter of building a strong socialist country with Chinese characteristics： adhere to the right path of governing the country， and promote Chinese path to modernization steadily with the momentum of innovation； Adhere to the original aspiration and mission， and meet the people’s needs for a better life with an innovative and pragmatic style； Adhere to the bottom line of rules and regulations， and carry out the great self revolution to the end with the spirit of innovation and change； Adhere to the lifeline of civilization and strive to build modern civilization of the Chinese nation with innovative development thinking.