Abstract: “Life and Practice”education emphasizes that education originates from life and practice, and its basic goal is to cultivate students’ self-supporting, living, learning, practice, cooperation and innovation, so as to promote students’all-around development. The comprehensive practical activity course carried out from its perspective can not only cultivate students’comprehensive quality and improve their “six forces”, but also has important practical significance for teachers to implement interdisciplinary research learning and “five education”integrated teaching. However, in the implementation process of comprehensive practical activity curriculum is faced with practical challenges such as the shallow understanding of curriculum connotation, the simplification of curriculum resource development, the neglect of the integration of “five education” in curriculum implementation, the difficulty of “interdisciplinary”in the implementation of activities and the biased curriculum evaluation. Therefore, teachers should have a deep understanding of the curriculum connotation, enrich the curriculum resource development type, update the curriculum implementation mode, and choose the correct evaluation method, so as to cope with these challenges.