Abstract: The Marxist theory of interaction is an important part of the materialist conception of history. Xi Jinping's cultural thoughts inherits Marx's humanistic theory of cultural interaction by adhering to the distinctive position of putting people first; it deepens Marx's theory of the dynamics of cultural interaction by focusing on the main body of cultural construction practice, prospering cultural undertakings and industries, and innovating cultural communication carriers; and it sublimates Marx's theory of the flow of information of cultural interaction by adhering to the concepts of equality and inclusiveness in the exchanges and mutual understanding of world civilizations and promoting the common values of all mankind. Xi Jinping's cultural thoughts is of great significance to the innovation and development of Marx's theory of cultural interaction, providing a guide for expanding new modes of cultural interaction and enriching people's spiritual world; providing spiritual power for maintaining social harmony and stability and realizing common prosperity; providing theoretical support for building a strong socialist culture and modern civilization of the Chinese nation; and providing practical guidance for building a community of human destiny and creating a new form of human civilization. It provides a practical guidance for building a community with a shared future for mankind and creating a new form of human civilization.