Abstract: The objective of this study aimed to investigate the relationship between college students' time management disposition, career decision-making self-efficacy and career decision-making anxiety, and the mediating effect of career decision-making self-efficacy between time management disposition and career decision-making anxiety. The research chosen 288 college students as subjects surveyed by using Adolescence Time Management Disposition Inventory, Career Decision-making Self-efficacy Scale and Career Decision-making Anxiety Scale. The study found that: (1) Among the three factors of time management disposition, the sense of time value has a significant positive predictive effect on career decision-making anxiety, the sense of time control and the sense of time efficacy have a significant negative predictive effect on career decision-making anxiety. (2) Career decision-making self-efficacy plays a suppressing effect between the sense of time value and career decision-making anxiety. The suppressing effect accounts for 79.73% of the direct effect. Career decision-making self-efficacy plays a mediating effect between the sense of time control, the sense of time efficacy and career decision-making anxiety. The mediating effect accounts for 60.79% and 63.09% of the total effect respectively. Conclusion: Career decision-making self-efficacy plays a mediating effect between college students' time management disposition and career decision-making anxiety.