Abstract: To explore the relationship between subjective well-being, social support and sense of the meaning of life for College Students, a total of 550 college students were investigated by using subjective well-being scale, perceived social support scale, and meaning life questionnaire. The results showed that:(1) social support and sense of the meaning of life were positively correlated with subjective well-being of college students; (2) social support and sense of the meaning of life had a positively predictive effect on subjective well-being of college students; (3) sense of meaning of life played a partial intermediary role between social support and subjective well-being of college students.