Abstract: In order to explore the relationship between general self-efficacy, social well-being and interpersonal trust in college freshmen, the general self-efficacy scale, social well-being scale and interpersonal trust scale were used to survey 394 college freshmen. The results show that: (1) There is a significant positive correlation between general self-efficacy and interpersonal trust in college freshmen; (2) Social well-being plays an intermediary role between general self-efficacy and social well-being among college freshmen. General self-efficacy is not only directly affects college freshmen interpersonal trust, but also indirectly affects college freshmen through social well-being.