Abstract: In the background of the huge impact of COVID-19 on various industries, the medical and health product e-commerce procurement index was selected to establish a VAR model to analyze the impact of COVID-19 on the medical and health product e-commerce consumption. It was found that COVID-19 had an impact on e-commerce consumption of medical and health products, which has a time attribute, gradually changing over time and having a time-lag effect. In order to control the epidemic situation of COVID-19 effectively, recommendations were made to reasonably guide the consumption of medical and health goods by e-commerce.