Abstract: Henry James is a novelist suffering from a mysterious disease all through his life, and has a special passion for diseases. In his literary creation, James emphasizes the value of disease subjects and effect of pathological characters, especially in The Portrait of a Lady where he provides us with a rich collage of such male characters. They are miraculously depicted and vividly drawn in the terms of the aesthetic view, romantic feeling and emotional factor, sketching out a series of lively images with character depth. Disease narration is a typical feature of James' writing of morbid life in his novels.