Abstract: The basic connotation of the great rejuvenation of the Chinese nation is that the country is prosperous and strong, the nation is rejuvenated, and the people are happy. It is the inevitable result of historical choice that the CPC takes up the historic responsibility of the great rejuvenation of the Chinese nation; The Chinese Communist Party takes up the responsibility of national great rejuvenation because of its incomparable advanced nature; The long and rich experience of the Chinese Communist Party in governing the country has provided a solid practical basis for it to bear the historical responsibility of the great rejuvenation of the Chinese nation. Upholding the leadership of the Party in all its work is the fundamental and vital lifeline of the Party and the country, as well as the interests and welfare of the people of all ethnic groups in the country. In the new era, the whole Party should strengthen its theoretical study, strengthen the "four self-confidence", ensure the "two safeguards", and ensure that under the strong leadership of the Communist Party of China, the goal of the great rejuvenation of the Chinese nation is achieved as scheduled.