Abstract: The mode of "school and local cooperation" helps to clarify the relationship between schools and local governments, schools and society, and win more room for the development of schools. The main problems at present are the lack of understanding of the innovation and entrepreneurship education, the poor design requirements of the pioneering and innovative education, the unsystematic construction of the curriculum system, the imperfect system design, and the insufficient guarantee of the innovation teachers. In order to solve these problems, we should combine the training with the needs of the local, set up the curriculum closely related with the local social and economic integration, and the entrepreneurial curriculum integrated the local with colleges and universities, elective courses closely related with the local economic and social development, cultivating the interest and specialty of the college students. From the perspective of college students innovation, we should build featured specialties, provide intellectual support for local economic and social development, establish a "university-local-university" model, enhance the combination of school and school, school and enterprise, and build a curriculum system and teaching staff of innovation and entrepreneurship education in local colleges and universities. Based on "school and local cooperation", an evaluation system of innovation and entrepreneurship education can be established.